| http://purl.uniprot.org/citations/10393183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10393183 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10393183 | http://www.w3.org/2000/01/rdf-schema#comment | "Ligand activation of the nuclear receptor PPARgamma induces adipogenesis and increases insulin sensitivity, while activation of other PPAR isoforms (-alpha and -delta) induces little or no fat cell differentiation. Expression and activation of chimeras formed between PPARgamma and PPARdelta in fibroblasts has allowed us to localize a major domain of PPARgamma responsible for adipogenesis to the N-terminal 138 amino acids, a region with AF-1 transcriptional activity. Using this region of PPARgamma as bait, we have used a yeast two-hybrid screen to clone a novel protein, termed PGC-2, containing a partial SCAN domain. PGC-2 binds to and increases the transcriptional activity of PPARgamma but does not interact with other PPARs or most other nuclear receptors. Ectopic expression of PGC-2 in preadipocytes containing endogenous PPARgamma causes a dramatic increase in fat cell differentiation at both the morphological and molecular levels. These results suggest that interactions between PGC-2, a receptor isoform-selective cofactor and PPARgamma contribute to the adipogenic action of this receptor."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.13.3676"xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.org/dc/terms/identifier | "doi:10.1093/emboj/18.13.3676"xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Spiegelman B.M."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Spiegelman B.M."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Hauser S."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Hauser S."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Wright M.E."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Wright M.E."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Park C.W."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Park C.W."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Castillo G."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Brun R.P."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Brun R.P."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Castillo G.C."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Rosenfield J.K."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Rosenfield J.K."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Troy A.E."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/author | "Troy A.E."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/10393183 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |