| http://purl.uniprot.org/citations/10393388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10393388 | http://www.w3.org/2000/01/rdf-schema#comment | "Pulmonary surfactant protein B (SP-B) is a 79 amino acid peptide that is intimately associated with surfactant phospholipids in the alveolar airspace. Mutations of the SP-B gene that result in complete absence of SP-B are invariably fatal in the neonatal period. The pathology associated with SP-B deficiency suggests that SP-B plays a critical role in integrating the synthesis, assembly and metabolism of the surfactant complex. A strategy is described to elucidate the role of SP-B in surfactant homeostasis by characterizing the pathophysiology associated with cell specific expression of SP-B constructs in vivo. Human SP-B constructs, under control of lung cell-specific promoters, were expressed in SP-B knockout mice in order to achieve expression of the human transgene in a null background. The effect of transgene expression on lung structure and function was assessed by biochemical, morphological and physiological analyses of the surfactant system in fetal and postnatal offspring."xsd:string |
| http://purl.uniprot.org/citations/10393388 | http://purl.org/dc/terms/identifier | "doi:10.1159/000047041"xsd:string |
| http://purl.uniprot.org/citations/10393388 | http://purl.uniprot.org/core/author | "Weaver T.E."xsd:string |
| http://purl.uniprot.org/citations/10393388 | http://purl.uniprot.org/core/author | "Beck D.C."xsd:string |
| http://purl.uniprot.org/citations/10393388 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10393388 | http://purl.uniprot.org/core/name | "Biol Neonate 76 Suppl"xsd:string |
| http://purl.uniprot.org/citations/10393388 | http://purl.uniprot.org/core/pages | "15-18"xsd:string |
| http://purl.uniprot.org/citations/10393388 | http://purl.uniprot.org/core/title | "Use of knockout mice to study surfactant protein structure and function."xsd:string |
| http://purl.uniprot.org/citations/10393388 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/10393388 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10393388 |
| http://purl.uniprot.org/citations/10393388 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10393388 |
| http://purl.uniprot.org/uniprot/#_P50405-mappedCitation-10393388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10393388 |
| http://purl.uniprot.org/uniprot/#_S4R239-mappedCitation-10393388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10393388 |
| http://purl.uniprot.org/uniprot/#_S4R2L6-mappedCitation-10393388 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10393388 |
| http://purl.uniprot.org/uniprot/P50405 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10393388 |
| http://purl.uniprot.org/uniprot/S4R2L6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10393388 |
| http://purl.uniprot.org/uniprot/S4R239 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10393388 |