| http://purl.uniprot.org/citations/10395673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10395673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10395673 | http://www.w3.org/2000/01/rdf-schema#comment | "This study investigates whether the guanine nucleotide exchange activity of Vav is linked to cytokine production in mast cells. Overexpression of Vav in the RBL-2H3 mast cell line resulted in the constitutive tyrosine phosphorylation and activation of Vav. We analyzed the functional effect of Vav overexpression on cytokine production. IL-2 and IL-6 mRNA levels were dramatically increased in Vav-overexpressing cells and correlated with increased NF-AT activity. Little or no effect was observed on the mRNA levels of IL-3, IL-4, GM-CSF, TNF-alpha, and TGF-beta. FcepsilonRI engagement did not further enhance IL-2 and IL-6 mRNA levels and only slightly enhanced NF-AT activity, but dramatically increased the mRNA levels of other tested cytokines. To understand the signal transduction required, we focused primarily on IL-6 induction by measuring mitogen-activated protein kinase activity and analyzing the effects of mutant or dominant negative forms of Vav, Rac1, and c-Jun N-terminal kinase-1 (JNK1). Vav overexpression resulted in the constitutive activation of JNK1 with little or no effect on p38 mitogen-activated protein kinase and ERK2. This was dependent on Vav-mediated activation of Rac1 as a Dbl domain-mutated Vav, inactive Rac N17, and inactive JNK1 down-regulated the Vav-induced JNK1 or IL-6 responses. Vav expression, but not expression of domain-mutated Vav, increased IL-6 secretion from nonimmortalized bone marrow-derived mast cells upon FcepsilonRI engagement. We conclude that Vav phosphorylation contributes to IL-6 induction in mast cells."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Gomez J."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Gomez J."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Rivera J."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Rivera J."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Song J.S."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Song J.S."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Scott P.M."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Scott P.M."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Tan T.-H."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Tan T.-H."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Haleem-Smith H."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Haleem-Smith H."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Mill J.F."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Mill J.F."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Arudchandran R."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/author | "Arudchandran R."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/pages | "802-810"xsd:string |
| http://purl.uniprot.org/citations/10395673 | http://purl.uniprot.org/core/pages | "802-810"xsd:string |