| http://purl.uniprot.org/citations/10397164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10397164 | http://www.w3.org/2000/01/rdf-schema#comment | "Progenitor cells of the T- and B-lineages in mice express (CD32) and Fc gamma RIII (CD16) but as the developing lymphocytes begin to express clonal antigen receptors, CD16 and CD32 are downregulated in T-cells, and CD16 is downregulated in B-cells. Considering that counter-receptors for Fc gamma R occur on thymic and bone marrow stromal cells, the possibility exists that Fc gamma R might participate in some aspect of T- and B-lineage development prior to the stage of antigen receptor expression. Previous studies provided evidence that Fc gamma R can influence murine T-lineage development. In the present studies we found that anti-Fc gamma RII/III mAb accelerated B-lineage development in bone marrow cultures from normal mice, but not in cultures from CD16-/- or CD32-/-mice. Similar results were observed when FACS-purified B-progenitor cells were co-cultured with BMS2, a bone marrow stromal cell line. Fresh bone marrow from CD32-/-mice contained about two-fold more B-lineage cells compared to bone marrow from normal or CD16-/-mice. These studies indicate that the Fc gamma R on B-lineage progenitor cells can influence their further development and add to a growing body of evidence that implicates Fc gamma R as regulatory elements in hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0165-2478(99)00038-3"xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/author | "Sandor M."xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/author | "Hagen M."xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/author | "de Andres B."xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/author | "Lynch R.G."xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/author | "Verbeek S."xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/author | "Rokhlin O."xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/name | "Immunol Lett"xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/pages | "109-113"xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/title | "A regulatory role for Fc gamma receptors (CD16 and CD32) in hematopoiesis."xsd:string |
| http://purl.uniprot.org/citations/10397164 | http://purl.uniprot.org/core/volume | "68"xsd:string |
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