| http://purl.uniprot.org/citations/10397259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10397259 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10397259 | http://www.w3.org/2000/01/rdf-schema#comment | "The GAGE-1 gene was identified previously as a gene that codes for an antigenic peptide, YRPRPRRY, which was presented on a human melanoma by HLA-Cw6 molecules and recognized by a clone of CTLs derived from the patient bearing the tumor. By screening a cDNA library from this melanoma, we identified five additional, closely related genes named GAGE-2-6. We report here that further screening of this library led to the identification of two more genes, GAGE-7B and -8. GAGE-1, -2, and -8 code for peptide YRPRPRRY. Using another antitumor CTL clone isolated from the same melanoma patient, we identified antigenic peptide, YYWPRPRRY, which is encoded by GAGE-3, -4, -5, -6, and -7B and which is presented by HLA-A29 molecules. Genomic cloning of GAGE-7B showed that it is composed of five exons. Sequence alignment showed that an additional exon, which is present only in the mRNA of GAGE-1, has been disrupted in gene GAGE-7B by the insertion of a long interspersed repeated element retroposon. These GAGE genes are located in the p11.2-p11.4 region of chromosome X. They are not expressed in normal tissues, except in testis, but a large proportion of tumors of various histological origins express at least one of these genes. Treatment of normal and tumor cultured cells with a demethylating agent, azadeoxycytidine, resulted in the transcriptional activation of GAGE genes, suggesting that their expression in tumors results from a demethylation process."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Brasseur F."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Brasseur F."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Boon T."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Boon T."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "van der Bruggen P."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "van der Bruggen P."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "De Plaen E."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "De Plaen E."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "De Smet C."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "De Smet C."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Arden K.C."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Arden K.C."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Viars C.S."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Viars C.S."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Czekay S."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Czekay S."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Boretti M."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Boretti M."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Chomez P."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "Chomez P."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "De Backer O."xsd:string |
| http://purl.uniprot.org/citations/10397259 | http://purl.uniprot.org/core/author | "De Backer O."xsd:string |