| http://purl.uniprot.org/citations/10400710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10400710 | http://www.w3.org/2000/01/rdf-schema#comment | "The transforming proteins of the small DNA tumor viruses, simian virus 40 (SV40), adenovirus, and human papillomavirus (HPV) target a number of identical cellular regulators whose functional abrogation is required for transformation. However, while both adenovirus E1A and SV40 large T transforming properties also depend on the targeting of the transcriptional coactivator CBP/p300, no such interaction has been described for the HPV oncoprotein E6 or E7. Here, we demonstrate that the HPV-16 E6 protein, previously shown to facilitate the degradation of p53 in a complex with E6-associated protein (E6AP), also targets CBP/p300 in an interaction involving the C-terminal zinc finger of E6 and CBP residues 1808 to 1826. Furthermore, this interaction is limited to E6 proteins of high-risk HPVs associated with cervical cancer that have the capacity to repress p53-dependent transcription. An HPV-16 E6 mutant (L50G) that binds CBP/p300, but not E6AP, is still capable of down-regulating p53 transcriptional activity. Thus, HPV E6 proteins possess two distinct mechanisms by which to abrogate p53 function: the repression of p53 transcriptional activity by targeting the p53 coactivator CBP/p300, and the removal of cellular p53 protein through the proteosome degradation pathway."xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.73.8.6209-6219.1999"xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/author | "Zimmermann H."xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/author | "Bernard H.U."xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/author | "O'Connor M.J."xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/author | "Degenkolbe R."xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/pages | "6209-6219"xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/title | "The human papillomavirus type 16 E6 oncoprotein can down-regulate p53 activity by targeting the transcriptional coactivator CBP/p300."xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://purl.uniprot.org/core/volume | "73"xsd:string |
| http://purl.uniprot.org/citations/10400710 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10400710 |
| http://purl.uniprot.org/citations/10400710 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10400710 |
| http://purl.uniprot.org/uniprot/P03126#attribution-B7BE1C78DBBBEE89E80A30CF2DB235B5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10400710 |