| http://purl.uniprot.org/citations/10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10409505 | http://www.w3.org/2000/01/rdf-schema#comment | "Erythropoietin is an essential growth factor that promotes survival, proliferation, and differentiation of mammalian erythroid progenitor cells. Erythropoietin(-/-) and erythropoietin receptor(-/-) mouse embryos die around embryonic day 13.5 due, in part, to failure of erythropoiesis in the fetal liver. In this study, we demonstrated a novel role of erythropoietin and erythropoietin receptor in cardiac development in vivo. We found that erythropoietin receptor is expressed in the developing murine heart in a temporal and cell type-specific manner: it is initially detected by embryonic day 10.5 and persists until day 14.5. Both erythropoietin(-/-) and erythropoietin receptor(-/-) embryos suffered from ventricular hypoplasia at day 12-13 of gestation. This defect appears to be independent from the general state of hypoxia and is likely due to a reduction in the number of proliferating cardiac myocytes in the ventricular myocardium. Cell proliferation assays revealed that erythropoietin acts as a mitogen in cells isolated from erythropoietin(-/-) mice, while it has no effect in hearts from erythropoietin receptor(-/-) animals. Erythropoietin(-/-) and erythropoietin receptor(-/-) embryos also suffered from epicardium detachment and abnormalities in the vascular network. Finally, through a series of chimeric analysis, we provided evidence that erythropoietin acts in a manner which is non-cell-autonomous. Our results elucidate a novel role of erythropoietin in cardiac morphogenesis and suggest a combination of anemia and cardiac failure as the cause of embryonic lethality in the erythropoietin(-/-) and erythropoietin receptor(-/-) animals."xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.126.16.3597"xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/author | "Gao J."xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/author | "Liu X."xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/author | "Wu H."xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/author | "Iruela-Arispe M.L."xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/pages | "3597-3605"xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/title | "Inactivation of erythropoietin leads to defects in cardiac morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/10409505 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10409505 |
| http://purl.uniprot.org/citations/10409505 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10409505 |
| http://purl.uniprot.org/uniprot/#_Q0VED9-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SRC0-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_A0A494B9T3-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_B1ARA9-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_B1ARB3-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_B7ZMY9-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_P62737-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_N0A5N9-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_Q3U122-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |
| http://purl.uniprot.org/uniprot/#_Q8CAW4-mappedCitation-10409505 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10409505 |