| http://purl.uniprot.org/citations/10410961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10410961 | http://www.w3.org/2000/01/rdf-schema#comment | "Catechol-O-methyltransferase (COMT) exists as two isoenzymes, a membrane-bound form (MB-COMT) and a soluble form (S-COMT), with different roles in the metabolism of catecholamines and other catechol compounds. This report documents an HPLC assay for separate estimation of S-COMT and MB-COMT activity and examines activities of the two isoenzymes among different rat tissues and in human and rat erythrocytes. Activities of MB-COMT and S-COMT varied widely among tissues. There were higher activities of S-COMT than MB-COMT in all tissues except the adrenal medulla where MB-COMT was the predominant isoenzyme, consistent with the importance of this tissue and MB-COMT for the O-methylation of catecholamines. MB-COMT and S-COMT in rat and human erythrocytes showed divergent levels and patterns of activity. The assay represents a rapid and accurate method for quantifying MB-COMT and S-COMT in various tissues and examining the relative roles of COMT isoenzymes in the metabolism of catechol compounds in health and disease."xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0378-4347(99)00125-5"xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/author | "Hooper D."xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/author | "Greenberg B.D."xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/author | "Eisenhofer G."xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/author | "Duddempudi S."xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/author | "Ellingson T."xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/name | "J Chromatogr B Biomed Sci Appl"xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/pages | "347-353"xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/title | "Determination of differential activities of soluble and membrane-bound catechol-O-methyltransferase in tissues and erythrocytes."xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://purl.uniprot.org/core/volume | "729"xsd:string |
| http://purl.uniprot.org/citations/10410961 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10410961 |
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