| http://purl.uniprot.org/citations/10412986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10412986 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial number and function are altered in response to external stimuli in eukaryotes. While several transcription/replication factors directly regulate mitochondrial genes, the coordination of these factors into a program responsive to the environment is not understood. We show here that PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs). PGC-1 stimulates a powerful induction of NRF-1 and NRF-2 gene expression; in addition, PGC-1 binds to and coactivates the transcriptional function of NRF-1 on the promoter for mitochondrial transcription factor A (mtTFA), a direct regulator of mitochondrial DNA replication/transcription. These data elucidate a pathway that directly links external physiological stimuli to the regulation of mitochondrial biogenesis and function."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)80611-x"xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Puigserver P."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Spiegelman B.M."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Troy A."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Andersson U."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Adelmant G."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Cinti S."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Scarpulla R.C."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Mootha V."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/author | "Lowell B."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/pages | "115-124"xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/title | "Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1."xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/10412986 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10412986 |
| http://purl.uniprot.org/citations/10412986 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10412986 |
| http://purl.uniprot.org/uniprot/#_Q06546-mappedCitation-10412986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10412986 |
| http://purl.uniprot.org/uniprot/#_Q06547-mappedCitation-10412986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10412986 |
| http://purl.uniprot.org/uniprot/#_Q16656-mappedCitation-10412986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10412986 |
| http://purl.uniprot.org/uniprot/#_Q5VV67-mappedCitation-10412986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10412986 |