| http://purl.uniprot.org/citations/10414952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10414952 | http://www.w3.org/2000/01/rdf-schema#comment | "An important aspect of the specification of neuronal fate is the choice of neurotransmitter. In Caenorhabditis elegans the neurotransmitter GABA is synthesized by the UNC-25 glutamic acid decarboxylase (GAD) and packaged into synaptic vesicles by the UNC-47 transporter. Both unc-25 and unc-47 are expressed in 26 GABAergic neurons of five different types. Previously, we have identified that the unc-30 homeobox gene controls the fate of 19 type D GABAergic neurons. We report here that the UNC-30 homeodomain protein transcriptionally regulates the expression of unc-25 and unc-47 in the 19 type D neurons. UNC-30 bound to the unc-25 and unc-47 promoters sequence-specifically. Mutations in the UNC-30 binding sites of the unc-25 and unc-47 promoters abolished the expression of reporter genes in the D neurons. The ectopic expression of UNC-30 induced the ectopic expression of reporter genes driven by the wild-type unc-25 and unc-47 promoters. Our data establish a mechanism for cell type-specific transcriptional coregulation of genes required for the synthesis and packaging of the neurotransmitter GABA."xsd:string |
| http://purl.uniprot.org/citations/10414952 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.19-15-06225.1999"xsd:string |
| http://purl.uniprot.org/citations/10414952 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/10414952 | http://purl.uniprot.org/core/author | "Horvitz H.R."xsd:string |
| http://purl.uniprot.org/citations/10414952 | http://purl.uniprot.org/core/author | "Eastman C."xsd:string |
| http://purl.uniprot.org/citations/10414952 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10414952 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/10414952 | http://purl.uniprot.org/core/pages | "6225-6234"xsd:string |
| http://purl.uniprot.org/citations/10414952 | http://purl.uniprot.org/core/title | "Coordinated transcriptional regulation of the unc-25 glutamic acid decarboxylase and the unc-47 GABA vesicular transporter by the Caenorhabditis elegans UNC-30 homeodomain protein."xsd:string |
| http://purl.uniprot.org/citations/10414952 | http://purl.uniprot.org/core/volume | "19"xsd:string |
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