| http://purl.uniprot.org/citations/10425199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10425199 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously identified an estrogen-responsive gene, efp (estrogen-responsive finger protein), by genomic binding-site cloning method. Here, we isolated a rat homologue of efp cDNA that encodes an open reading frame of 644 amino acids sharing high homology with human efp (69% identity at the protein level) and mouse efp (80% identity at the protein level). The efp protein has a RING finger, a variant type of zinc finger motif, B1 box and B2 box, each having a pair of zinc fingers, and coiled-coil domain, belonging to the RING finger-B box-Coiled Coil (RBCC) family. Several members of RBCC family including efp have characteristic C-terminal domain, forming a subfamily. Next, we detected efp mRNA in primary osteoblasts, one of estrogen target cells, derived from the calvariae of rat fetus. An anti-efp antibody revealed the efp protein is expressed and regulated by estrogen in the primary osteoblasts. Interestingly, the efp protein in primary osteoblasts is down-regulated by 1alpha,25-dihydroxyvitamin D(3) treatment that promotes the differentiation of the cells, whereas it is up-regulated by TGF-beta1 treatment that inhibits the differentiation of the cells. These findings suggest the possible involvement of the efp in the differentiation of osteoblastic cells."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.0874"xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/author | "Inoue S."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/author | "Muramatsu M."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/author | "Urano T."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/author | "Ouchi Y."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/author | "Orimo A."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/author | "Hosoi T."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/pages | "412-418"xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/title | "Molecular cloning of rat efp: expression and regulation in primary osteoblasts."xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://purl.uniprot.org/core/volume | "261"xsd:string |
| http://purl.uniprot.org/citations/10425199 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10425199 |
| http://purl.uniprot.org/citations/10425199 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10425199 |
| http://purl.uniprot.org/uniprot/A6HHZ8#attribution-9A16173D6F335FD1446A93ECC6F86F71 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10425199 |
| http://purl.uniprot.org/uniprot/A6HHZ9#attribution-9A16173D6F335FD1446A93ECC6F86F71 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10425199 |
| http://purl.uniprot.org/uniprot/Q6P7B3#attribution-9A16173D6F335FD1446A93ECC6F86F71 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10425199 |
| http://purl.uniprot.org/uniprot/D4A9N5#attribution-9A16173D6F335FD1446A93ECC6F86F71 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10425199 |
| http://purl.uniprot.org/uniprot/#_D4A9N5-mappedCitation-10425199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10425199 |
| http://purl.uniprot.org/uniprot/#_Q6P7B3-mappedCitation-10425199 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10425199 |
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