| http://purl.uniprot.org/citations/10425206 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10425206 | http://www.w3.org/2000/01/rdf-schema#comment | "The peroxisome-proliferator activated receptor gamma (PPARgamma), a member of the nuclear receptor superfamily of ligand activated transcription factors, plays a key role in the anti-diabetic actions of the thiazolidinediones (TZDs). PPARgamma induces the expression of many genes involved in lipid anabolism, including the adipocyte fatty acid binding protein (aP2), and is a key regulator of adipocyte differentiation. PPARgamma is also expressed in hematopoietic cells and is up-regulated in activated monocytes/macrophages. Activation of PPARgamma may play a role in the induction of differentiation of macrophages to foam cells that are associated with atherosclerotic lesions. We report that both natural and synthetic PPARgamma agonists induce time- and dose-dependent increases in aP2 mRNA in both primary human monocytes and the monocytic cell line, THP-1. These data suggest that PPARgamma activation may play a role in monocyte differentiation and function analogous to its well-characterized role in adipocytes."xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.1071"xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/author | "Demarest K.T."xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/author | "Burris T.P."xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/author | "Pelton P.D."xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/pages | "456-458"xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/title | "PPARgamma activation induces the expression of the adipocyte fatty acid binding protein gene in human monocytes."xsd:string |
| http://purl.uniprot.org/citations/10425206 | http://purl.uniprot.org/core/volume | "261"xsd:string |
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