| http://purl.uniprot.org/citations/10430869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10430869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10430869 | http://www.w3.org/2000/01/rdf-schema#comment | "AP-2 adaptors regulate clathrin-bud formation at the cell surface by recruiting clathrin trimers to the plasma membrane and by selecting certain membrane proteins for inclusion within the developing clathrin-coat structure. These functions are performed by discrete subunits of the adaptor heterotetramer. The carboxyl-terminal appendage of the AP-2 alpha subunit appears to regulate the translocation of several endocytic accessory proteins to the bud site. We have determined the crystal structure of the alpha appendage at 1.4-A resolution by multiwavelength anomalous diffraction phasing. It is composed of two distinct structural modules, a beta-sandwich domain and a mixed alpha-beta platform domain. Structure-based mutagenesis shows that alterations to the molecular surface of a highly conserved region on the platform domain differentially affect associations of the appendage with amphiphysin, eps15, epsin, and AP180, revealing a common protein-binding interface."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.16.8907"xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.16.8907"xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/author | "Fremont D.H."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/author | "Fremont D.H."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/author | "Traub L.M."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/author | "Traub L.M."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/author | "Downs M.A."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/author | "Downs M.A."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/author | "Westrich J.L."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/author | "Westrich J.L."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/pages | "8907-8912"xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/pages | "8907-8912"xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/title | "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/title | "Crystal structure of the alpha appendage of AP-2 reveals a recruitment platform for clathrin-coat assembly."xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10430869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10430869 |
| http://purl.uniprot.org/citations/10430869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10430869 |