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| http://purl.uniprot.org/citations/10433270 | http://www.w3.org/2000/01/rdf-schema#comment | "Biochemical studies suggest that syntaxin 1A participates in multiple protein-protein interactions in the synaptic terminal, but the in vivo significance of these interactions is poorly understood. We used a targeted mutagenesis approach to eliminate specific syntaxin binding interactions and demonstrate that Drosophila syntaxin 1A plays multiple regulatory roles in neurotransmission in vivo. Syntaxin mutations that eliminate ROP/Munc-18 binding display increased neurotransmitter release, suggesting that ROP inhibits neurosecretion through its interaction with syntaxin. Syntaxin mutations that block Ca2+ channel binding also cause an increase in neurotransmitter release, suggesting that syntaxin normally functions in inhibiting Ca2+ channel opening. Additionally, we identify and characterize a syntaxin Ca2+ effector domain, which may spatially organize the Ca2+ channel, cysteine string protein, and synaptotagmin for effective excitation-secretion coupling in the presynaptic terminal."xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(00)80811-9"xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/author | "He Y."xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/author | "Bellen H.J."xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/author | "Wu M.N."xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/author | "Broadie K."xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/author | "Fergestad T."xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/author | "Lloyd T.E."xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/pages | "593-605"xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/title | "Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo."xsd:string |
| http://purl.uniprot.org/citations/10433270 | http://purl.uniprot.org/core/volume | "23"xsd:string |
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