| http://purl.uniprot.org/citations/10433800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10433800 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10433800 | http://www.w3.org/2000/01/rdf-schema#comment | "Numerous proteins are cleaved or "shed" from their membrane-bound form. One such protein, tumour necrosis factor alpha (TNF-alpha), is synthesized as a type 2 transmembrane protein. Recently, a human protease responsible for this shedding, the TNF-alpha converting enzyme (TACE/ADAM17), was isolated. TACE/ADAM17 is a member of the adamalysin class of zinc-binding metalloproteases or ADAM (a disintegrin and metalloprotease). We report the isolation and characterization of the mouse TACE/ADAM17 cDNA and gene. Mouse TACE/ADAM17 has a 92% amino-acid identity with the human protein and was ubiquitously expressed. A recombinant form of the protease is found to cleave a peptide representing the cleavage site of precursor mouse TNF-alpha. An alternatively spliced form of mouse TACE/ADAM17 was found that would produce a soluble protein. The gene for TACE/ADAM17 is approximately 50 kb and contains 19 exons. Chromosomal mapping places TACE/ADAM17 on mouse chromosome 12 and human chromosome 2p25."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.org/dc/terms/identifier | "doi:10.1006/cyto.1998.0466"xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.org/dc/terms/identifier | "doi:10.1006/cyto.1998.0466"xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Nelson N."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Nelson N."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Copeland N.G."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Gilbert D.J."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Gilbert D.J."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Jenkins N.A."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Black R.A."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Black R.A."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Castner B.J."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Castner B.J."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Cerretti D.P."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Cerretti D.P."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Means G."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Means G."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Poindexter K."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/author | "Poindexter K."xsd:string |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10433800 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |