| http://purl.uniprot.org/citations/10433821 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10433821 | http://www.w3.org/2000/01/rdf-schema#comment | "Hair follicle development serves as an excellent model to study control of organ morphogenesis. Three specific isoforms of TGF-beta exist which exhibit a distinct pattern of expression during hair follicle morphogenesis. To clarify the still elusive role of these factors in hair follicle development, we have used a combined genetic and functional approach: analysis of hair follicle development in mice with disruptions of the TGF-beta1, 2, and 3 genes was coupled with a direct functional test of the effect of added purified factors on fetal hair follicle development in skin organ cultures. TGF-beta2 null mice exhibited a profound delay of hair follicle morphogenesis, with a 50% reduced number of hair follicles. In contrast to hair follicle development, growth and differentiation of interfollicular keratinocytes proceeded unimpaired. Unlike TGF-beta2-/-mice, mice with a disruption of the TGF-beta1 gene showed slightly advanced hair follicle formation, while lack of the TGF-beta3 gene did not have any effects. Treatment of wild-type, embryonic skin explants (E14.5 or E15.5) with TGF-beta2 protein in either soluble form or slow release beads induced hair follicle development and epidermal hyperplasia, while similar TGF-beta1 treatment exerted suppressive effects. Thus, the TGF-beta2 isoform plays a specific role, not shared by the other TGF-beta isoforms, as an inducer of hair follicle morphogenesis and is both required and sufficient to promote this process."xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.org/dc/terms/identifier | "doi:10.1006/dbio.1999.9325"xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/author | "Paus R."xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/author | "Doetschman T."xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/author | "Dotto G.P."xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/author | "Foitzik K."xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/name | "Dev Biol"xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/pages | "278-289"xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/title | "The TGF-beta2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/10433821 | http://purl.uniprot.org/core/volume | "212"xsd:string |
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