| http://purl.uniprot.org/citations/10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10435582 | http://www.w3.org/2000/01/rdf-schema#comment | "Signaling through the pre-TCR is essential for early T cell development and is severely impaired in mice lacking the CD3 gamma chain of the pre-TCR. We here address the molecular mechanisms underlying this defect. Impaired pre-TCR signaling is shown to be associated with a profound increase in the number of apoptotic CD4- CD8-(DN) thymocytes. Introduction of p53 deficiency into CD3 gamma-deficient mice completely reverses the cell survival defect in CD3 gamma-deficient DN thymocytes and rescues the block in pre-T cell differentiation. In addition, the CD4+ CD8+ (DP) compartment is expanded to its normal size. These findings suggest that the pre-TCR regulates progression through the DNA-damage checkpoint of the DN to DP transition by inactivating p53."xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1074-7613(00)80084-9"xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/author | "Krimpenfort P."xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/author | "Haks M.C."xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/author | "Kruisbeek A.M."xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/author | "van den Brakel J.H."xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/pages | "91-101"xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/title | "Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells."xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/10435582 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10435582 |
| http://purl.uniprot.org/citations/10435582 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10435582 |
| http://purl.uniprot.org/uniprot/#_E0CXP3-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
| http://purl.uniprot.org/uniprot/#_A0A5Q0MU23-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
| http://purl.uniprot.org/uniprot/#_I7HIK9-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
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| http://purl.uniprot.org/uniprot/#_Q3U4Y3-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
| http://purl.uniprot.org/uniprot/#_P15919-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
| http://purl.uniprot.org/uniprot/#_Q3UGQ1-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
| http://purl.uniprot.org/uniprot/#_O70366-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
| http://purl.uniprot.org/uniprot/#_Q80ZA1-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |
| http://purl.uniprot.org/uniprot/#_P11942-mappedCitation-10435582 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10435582 |