| http://purl.uniprot.org/citations/10435629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10435629 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10435629 | http://www.w3.org/2000/01/rdf-schema#comment | "To determine the frequency of Wnt/Wingless beta catenin pathway alteration in human hepatocellular carcinoma, a beta catenin and APC gene mutation screening was performed in a series of 119 tumors. An activating beta catenin mutation in exon 3 was found in 18% of the cases. Among tumors lacking beta catenin mutation, no APC mutation has been evidenced in a subset of 30 cases tested. The correlation between beta catenin mutation status and chromosome segment deletions was studied on a set of 48 hyperploid tumors. Chromosome 1p, 4q and 16p deletions were significantly associated with the absence of beta catenin mutation (P<0.05). Furthermore the Fractional Allelic Loss was significantly smaller in the beta catenin mutated tumors than in the non-mutated tumors (0.12 versus 022). Taken together, these results suggest, the existence of two carcinogenesis mechanisms. The first mechanism implies a beta catenin activating mutation associated with a low rate of loss of heterozygosity. The second mechanism, operating in a context of chromosomal instability, would involve tumor suppressor genes."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202800"xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1202800"xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Thomas G."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Laurent-Puig P."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Laurent-Puig P."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Franco D."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Franco D."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Perret C."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Perret C."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Balabaud C."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Balabaud C."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Bayer J."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Bayer J."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Belghiti J."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Belghiti J."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Bluteau O."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Bluteau O."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Legoix P."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Legoix P."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Zucman-Rossi J."xsd:string |
| http://purl.uniprot.org/citations/10435629 | http://purl.uniprot.org/core/author | "Zucman-Rossi J."xsd:string |