| http://purl.uniprot.org/citations/10438949 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10438949 | http://www.w3.org/2000/01/rdf-schema#comment | "The BCL-6 gene negatively regulates Th2 responses as shown by the finding that BCL-6-deficient (BCL-6-/-) mice develop a lethal Th2-type inflammatory disease. The response of inbred mouse strains to infection with Leishmania major is under genetic control; BALB/c mice are susceptible and develop a progressive parasite burden, whereas most other common laboratory strains of mice are resistant to infection. We found that BCL-6-/-mice on a resistant genetic background (C57BL/6 x 129 intercrossed mice) were highly susceptible to L. major infection; they resembled BALB/c mice in terms of lesion size, parasite load, and the production of Th2 cytokines. BCL-6-/-IL-4-/-double-mutant mice were also susceptible to L. major infection and produced 10-fold higher levels of the Th2 cytokine IL-13 than IL-4-/-littermate controls. By contrast, BCL-6-/-STAT6-/-double-mutant mice were resistant to L. major infection despite also producing elevated levels of IL-13. These results show that STAT6 is required for susceptibility to L. major infection and suggest that IL-13 signaling through STAT6 may contribute to a nonhealing, exacerbated L. major infection."xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/author | "Sher A."xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/author | "Staudt L.M."xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/author | "Paul W.E."xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/author | "Dent A.L."xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/author | "Doherty T.M."xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/pages | "2098-2103"xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/title | "BCL-6-deficient mice reveal an IL-4-independent, STAT6-dependent pathway that controls susceptibility to infection by Leishmania major."xsd:string |
| http://purl.uniprot.org/citations/10438949 | http://purl.uniprot.org/core/volume | "163"xsd:string |
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