| http://purl.uniprot.org/citations/10438950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10438950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10438950 | http://www.w3.org/2000/01/rdf-schema#comment | "We have characterized a novel cDNA whose steady state mRNA levels rise in the thymus 2 to 6 h following the induction of CD4+CD8+ thymocyte apoptosis by in vivo cross-linking of CD3 epsilon. This cDNA, AND-34-1, contains an open reading frame (ORF) encoding a protein with an amino-terminal Src homology 2 (SH2) domain and a carboxyl-terminal domain homologous to GDP-exchange factors (GEFs). Northern analysis demonstrates widespread expression of the AND-34 gene. Anti-CD3 epsilon treatment induces up-regulation of the AND-34 mRNA levels in total thymic RNA but not in RNA from purified thymocytes, suggesting that this transcript is derived from a thymic stromal cell population. IL-1 and TNF increase AND-34 transcript levels in thymic cortical reticular, thymic nurse, and fibroblast cell lines. In the thymic cortical reticular cell line, IL-1 and TNF induce a protein of the predicted 93-kDa size reactive with anti-AND-34 peptide antisera. Fifteen minutes of serum stimulation of vanadate-pretreated AND-34-1-transfected NIH3T3 fibroblasts induces tyrosine phosphorylation of AND-34 as well as coprecipitating 95-, 125-, and 130-kDa proteins. One of these tyrosine phosphorylated proteins is identified as p130Cas (Crk-associated substrate), a signaling molecule previously known to bind to a GDP-exchange factor (C3G) and inducibly associate with the focal adhesion complex. Consistent with such an association, AND-34 tyrosine phosphorylation is induced following adherence of trypsinized fibroblasts to fibronectin or poly-L -lysine-coated surfaces."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/author | "Cai D."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/author | "Cai D."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/author | "Clayton L.K."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/author | "Clayton L.K."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/author | "Lerner A."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/author | "Lerner A."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/author | "Smolyar A."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/author | "Smolyar A."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/name | "J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/pages | "2104-2112"xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/pages | "2104-2112"xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/title | "AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/title | "AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines."xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/volume | "163"xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://purl.uniprot.org/core/volume | "163"xsd:string |
| http://purl.uniprot.org/citations/10438950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10438950 |
| http://purl.uniprot.org/citations/10438950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10438950 |
| http://purl.uniprot.org/citations/10438950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10438950 |
| http://purl.uniprot.org/citations/10438950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10438950 |