http://purl.uniprot.org/citations/10440244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/10440244 | http://www.w3.org/2000/01/rdf-schema#comment | "PurposeBehçet's disease (BD) is known to be associated with HLA-B51 in many different ethnic groups. Recently MICA, a member of a novel family of the human major histocompatibility complex (MHC) class I genes termed MIC (MHC class I chain-related genes), was identified near the HLA-B gene, and a triplet repeat microsatellite polymorphism was found in the transmembrane (TM) region. Because a strong association with BD of one particular MICA-TM allele, A6, was shown in a Japanese population, the present study was conducted to investigate microsatellite polymorphism in Greek patients with BD to know whether this association is generally observed in BD occurring in other populations.MethodsThirty-eight Greek patients with BD and 40 ethnically matched control subjects were examined for MICA microsatellite polymorphism using polymerase chain reaction (PCR) and subsequent automated fragment detection by fluorescent-based technology.ResultsSimilar to the Japanese patients with BD, the phenotype frequency of the MICA-TM A6 allele was significantly increased in the Greek patients with BD (50.0% in control subjects versus 86.8% in BD cases), with an odds ratio (OR) of 6.60 (P = 0.0012). The MICA-A6 allele was found in a high frequency both in males and females (weighted OR = 6.68; P = 0.0017). No association was found between the A6 allele and several disease features. A strong association exists between the MICA-TM A6 allele and the B*5101 allele in both the control subjects and patients with BD (weighted OR = 44.39; P = 0.0000023).ConclusionsThis study revealed in Greek patients a strong association of BD with a particular MICA-TM allele, MICA-A6, providing insight into the molecular mechanism underlying the development of BD."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Inoko H."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Ohno S."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Katsuyama Y."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Ota M."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Yabuki K."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Mizuki N."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Giziaki E."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Kaklamani E."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Kaklamani V."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Koumantaki Y."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Palimeris G."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Spyropoulou M."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/author | "Stavropoulos C."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/name | "Invest Ophthalmol Vis Sci"xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/pages | "1921-1926"xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/title | "Association of MICA gene and HLA-B*5101 with Behcet's disease in Greece."xsd:string |
http://purl.uniprot.org/citations/10440244 | http://purl.uniprot.org/core/volume | "40"xsd:string |
http://purl.uniprot.org/citations/10440244 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10440244 |
http://purl.uniprot.org/citations/10440244 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10440244 |
http://purl.uniprot.org/uniprot/#_A0A0A7C552-mappedCitation-10440244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10440244 |
http://purl.uniprot.org/uniprot/#_A0A0E3DC98-mappedCitation-10440244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10440244 |
http://purl.uniprot.org/uniprot/#_A0A0E3DCA0-mappedCitation-10440244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10440244 |