| http://purl.uniprot.org/citations/10440375 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10440375 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10440375 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurotransmitter release at synapses between nerve cells is mediated by calcium-triggered exocytotic fusion of synaptic vesicles. Before fusion, vesicles dock at the presynaptic release site where they mature to a fusion-competent state. Here we identify Munc13-1, a brain-specific presynaptic phorbol ester receptor, as an essential protein for synaptic vesicle maturation. We show that glutamatergic hippocampal neurons from mice lacking Munc13-1 form ultrastructurally normal synapses whose synaptic-vesicle cycle is arrested at the maturation step. Transmitter release from mutant synapses cannot be triggered by action potentials, calcium-ionophores or hypertonic sucrose solution. In contrast, release evoked by alpha-latrotoxin is indistinguishable from wild-type controls, indicating that the toxin can bypass Munc13-1-mediated vesicle maturation. A small subpopulation of synapses of any given glutamatergic neuron as well as all synapses of GABA (gamma-aminobutyric acid)-containing neurons are unaffected by Munc13-1 loss, demonstrating the existence of multiple and transmitter-specific synaptic vesicle maturation processes in synapses."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.org/dc/terms/identifier | "doi:10.1038/22768"xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.org/dc/terms/identifier | "doi:10.1038/22768"xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/author | "Suedhof T.C."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/author | "Brose N."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/author | "Brose N."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/author | "Augustin I."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/author | "Augustin I."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/pages | "457-461"xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/pages | "457-461"xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/title | "Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/title | "Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles."xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/volume | "400"xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://purl.uniprot.org/core/volume | "400"xsd:string |
| http://purl.uniprot.org/citations/10440375 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10440375 |
| http://purl.uniprot.org/citations/10440375 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10440375 |