| http://purl.uniprot.org/citations/10441328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10441328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10441328 | http://www.w3.org/2000/01/rdf-schema#comment | "Spinocerebellar ataxia type 7 (SCA7) belongs to a group of neurological disorders caused by a CAG repeat expansion in the coding region of the associated gene. To gain insight into the pathogenesis of SCA7 and possible functions of ataxin-7, we examined the subcellular localization of ataxin-7 in transfected COS-1 cells using SCA7 cDNA clones with different CAG repeat tract lengths. In addition to a diffuse distribution throughout the nucleus, ataxin-7 associated with the nuclear matrix and the nucleolus. The location of the putative SCA7 nuclear localization sequence (NLS) was confirmed by fusing an ataxin-7 fragment with the normally cytoplasmic protein chicken muscle pyruvate kinase. Mutation of this NLS prevented protein from entering the nucleus. Thus, expanded ataxin-7 may carry out its pathogenic effects in the nucleus by altering a matrix-associated nuclear structure and/or by disrupting nucleolar function."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/8.9.1657"xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.org/dc/terms/identifier | "doi:10.1093/hmg/8.9.1657"xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Koob M.D."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Koob M.D."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Ranum L.P."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Ranum L.P."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Duvick L.A."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Duvick L.A."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Kaytor M.D."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Kaytor M.D."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Skinner P.J."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/author | "Skinner P.J."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/name | "Hum. Mol. Genet."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/pages | "1657-1664"xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/pages | "1657-1664"xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/title | "Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7."xsd:string |
| http://purl.uniprot.org/citations/10441328 | http://purl.uniprot.org/core/title | "Nuclear localization of the spinocerebellar ataxia type 7 protein, ataxin-7."xsd:string |