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http://purl.uniprot.org/citations/10441496http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10441496http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10441496http://www.w3.org/2000/01/rdf-schema#comment"Apaf-1, the human C. elegans Ced-4 homologue, plays a crucial role in mitochondrial mediated apoptosis. To determine whether a mutant Apaf-1 is involved in the pathogenesis of malignant lymphomas, we performed sequence analysis of its transcriptional gene product. Therefore, cDNAs coding for Apaf-1 were examined in six lymphoma derived cell lines, in three non-lymphoid tumor cell lines, as well as in peripheral blood lymphocytes and in tissue from heart, kidney, and liver by RT-PCR. These studies did not disclose the expected tumor related alterations but led instead to the identification of three novel forms of Apaf-1. These forms vary in length, but contain all functional domains formerly characterized in the Apaf-1 protein. The results indicate that the previously published sequence is not the Apaf-1 form most widely expressed."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.1999.1124"xsd:string
http://purl.uniprot.org/citations/10441496http://purl.org/dc/terms/identifier"doi:10.1006/bbrc.1999.1124"xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Stein H."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Stein H."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Duerkop H."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Duerkop H."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Hahn C."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Hahn C."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Hirsch B."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Hirsch B."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Jahnke D."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/author"Jahnke D."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/name"Biochem. Biophys. Res. Commun."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/pages"746-749"xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/pages"746-749"xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/title"Three new types of Apaf-1 in mammalian cells."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/title"Three new types of Apaf-1 in mammalian cells."xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/volume"261"xsd:string
http://purl.uniprot.org/citations/10441496http://purl.uniprot.org/core/volume"261"xsd:string