| http://purl.uniprot.org/citations/10444455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10444455 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10444455 | http://www.w3.org/2000/01/rdf-schema#comment | "Enteric nematode infections lead to increased interleukin (IL)-5 expression, eosinophilic inflammation, and intestinal smooth muscle hypercontractility. Although eosinophils release inflammatory mediators that cause smooth muscle contraction, the role of IL-5 and eosinophils in enteric smooth muscle hypercontractility is unclear. IL-5-deficient mice and their wild-type controls were infected with the nematode Trichinella spiralis. Intestinal parasites and eosinophils were counted, and jejunal longitudinal muscle contractility was assessed. During infection, IL-5 gene expression increased significantly in wild-type mice and was accompanied by significant intestinal eosinophilia in wild-type but not IL-5-deficient mice. Although both strains developed increased muscle contractility during infection, contraction was significantly less in the IL-5-deficient mice at days 16 and 21 postinfection. In addition, parasite expulsion was transiently delayed at day 16 in IL-5-deficient mice. Thus, in the nematode-infected mouse, IL-5 appears essential for intestinal eosinophilia and contributes to, but is not essential for, the development of muscle hypercontractility. IL-5 also appears to play a minor role in expelling a primary T. spiralis infection from the gut."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.1999.277.2.g400"xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpgi.1999.277.2.g400"xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Deng Y."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Young I.G."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Young I.G."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Vallance B.A."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Vallance B.A."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Matthaei K.I."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Matthaei K.I."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Blennerhassett P.A."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Blennerhassett P.A."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Collins S.M."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/author | "Collins S.M."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/name | "Am. J. Physiol."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/pages | "G400-G408"xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/pages | "G400-G408"xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/title | "IL-5 contributes to worm expulsion and muscle hypercontractility in a primary T. spiralis infection."xsd:string |
| http://purl.uniprot.org/citations/10444455 | http://purl.uniprot.org/core/title | "IL-5 contributes to worm expulsion and muscle hypercontractility in a primary T. spiralis infection."xsd:string |