| http://purl.uniprot.org/citations/10449770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10449770 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10449770 | http://www.w3.org/2000/01/rdf-schema#comment | "Engagement of the T cell antigen receptor (TCR) leads to rapid activation of protein tyrosine kinases, which in turn phosphorylate downstream enzymes and adapter proteins. Some adapter proteins, such as SLP-76, Vav, and LAT, positively regulate TCR-mediated signal transduction, whereas others, such as Cbl, play an inhibitory role. SLAP (Src-like adapter protein), an adapter protein containing a Src homology 3 and a Src homology 2 domain, was isolated from a yeast interacting screen by using N-terminal Cbl as bait. N-terminal Cbl interacts with SLAP in vivo and in vitro in a tyrosine phosphorylation-independent manner. We observed that SLAP is expressed in T cells, and upon TCR activation, SLAP interacts with ZAP-70, Syk, LAT, and TCRzeta chain in Jurkat T cells. In transiently transfected COS-7 cells, SLAP forms separate complexes with ZAP-70, Syk, and LAT through its Src homology 2 domain. Overexpression of a C-terminal-truncated SLAP mutant down-regulates nuclear factor of activated T cells-AP1 activity. We have evidence that SLAP forms homodimers through its C-terminal region. Serial truncations and mutations in the C terminus of SLAP demonstrate that there is a correlation between the loss of dimerization and the inhibition of nuclear factor of activated T cells-AP1 activity. The in vivo association of SLAP with key signaling molecules and its inhibition of T cell activation suggests that SLAP plays an important role in TCR-mediated signal transduction."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.17.9775"xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.17.9775"xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/author | "Tang J."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/author | "Chang J.-H."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/author | "Chang J.-H."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/author | "Burakoff S.J."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/author | "Burakoff S.J."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/author | "Sawasdikosol S."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/author | "Sawasdikosol S."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/pages | "9775-9780"xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/pages | "9775-9780"xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/title | "SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/title | "SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling."xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10449770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10449770 |
| http://purl.uniprot.org/citations/10449770 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10449770 |