| http://purl.uniprot.org/citations/10452993 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10452993 | http://www.w3.org/2000/01/rdf-schema#comment | "Homozygous HLA-A2.1 transgenic H-2KbnullDbnull double knockout (KO) mice were created. Their potential to develop HLA-A2. 1-restricted cytolytic responses was compared with that of their classical transgenic counterparts, which still express H-2Kb, Db molecules. On cell surfaces, both strains express similar amounts of chimeric (alpha 1 alpha 2 domains of human, alpha 3 cytoplasmic domains of mouse) HLA-A2.1 molecules in noncovalent association with mouse beta 2-microglobulin. Compared with mice that are totally deprived of histocompatibility class Ia molecules (H-2KbnullDbnull double KO), the expression of HLA-A2.1 in transgenic/double KO mice resulted in sizeable increase in the periphery of CD8+ T cells with a normally diversified TCR repertoire. A biased education in favor of HLA-A2.1, ascribable to the absence of H-2 class Ia molecules, was evidenced in these transgenic/double KO mice by their improved capacity to mount HLA-restricted cytolytic responses, regardless of whether they were virally infected or injected with synthetic epitopic peptide. HLA class I transgenic, H-2 class Ia KO mice should represent useful animal models for the preclinical evaluation of vaccine formulations aiming at the induction of HLA class I-restricted CTL responses."xsd:string |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/author | "Ureta-Vidal A."xsd:string |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/author | "Lemonnier F.A."xsd:string |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/author | "Perarnau B."xsd:string |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/author | "Firat H."xsd:string |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/pages | "2555-2560"xsd:string |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/title | "Phenotypical and functional characterization of the CD8+ T cell repertoire of HLA-A2.1 transgenic, H-2KbnullDbnull double knockout mice."xsd:string |
| http://purl.uniprot.org/citations/10452993 | http://purl.uniprot.org/core/volume | "163"xsd:string |
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