| http://purl.uniprot.org/citations/10455105 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10455105 | http://www.w3.org/2000/01/rdf-schema#comment | "Presynaptic voltage-gated calcium (Ca(2+)) channels mediate Ca(2+) influx into the presynaptic terminal that triggers synaptic vesicle fusion and neurotransmitter release. The immediate proximity of Ca(2+) channels to the synaptic vesicle release apparatus is critical for rapid and efficient synaptic transmission. In a series of biochemical experiments, we demonstrate a specific association of the cytosolic carboxyl terminus of the N-type Ca(2+) channel pore-forming alpha(1B) subunit with the modular adaptor proteins Mint1 and CASK. The carboxyl termini of alpha(1B) bind to the first PDZ domain of Mint1 (Mint1-1). The proline-rich region present in the carboxyl termini of alpha(1B) binds to the SH3 domain of CASK. Mint1-1 is specific for the E/D-X-W-C/S-COOH consensus, which defines a novel class of PDZ domains (class III). The Mint1-1 PDZ domain-binding motif is present only in the "long" carboxyl-terminal splice variants of N-type (alpha(1B)) and P/Q-type (alpha(1A)) Ca(2+) channels, but not in R-type (alpha(1E)) or L-type (alpha(1C)) Ca(2+) channels. Our results directly link presynaptic Ca(2+) channels to a macromolecular complex formed by modular adaptor proteins at synaptic junction and advance our understanding of coupling between cell adhesion and synaptic vesicle exocytosis."xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.35.24453"xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://purl.uniprot.org/core/author | "Sudhof T.C."xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://purl.uniprot.org/core/author | "Bezprozvanny I."xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://purl.uniprot.org/core/author | "Maximov A."xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10455105 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://purl.uniprot.org/core/pages | "24453-24456"xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://purl.uniprot.org/core/title | "Association of neuronal calcium channels with modular adaptor proteins."xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/10455105 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10455105 |
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