| http://purl.uniprot.org/citations/10464340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10464340 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10464340 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular basis for glutamate receptor trafficking to the plasma membrane is not understood. In the present study, we demonstrate that Homer 1b (H1b), a constitutively expressed splice form of the immediate early gene product Homer (now termed Homer 1a) regulates the trafficking and surface expression of group I metabotropic glutamate receptors. H1b inhibits surface expression of the metabotropic glutamate receptor mGluR5 in heterologous cells, causing mGluR5 to be retained in the endoplasmic reticulum (ER). In contrast, mGluR5 alone or mGluR5 coexpressed with Homer 1a successfully travels through the secretory pathway to the plasma membrane. In addition, point mutations that disrupt mGluR5 binding to H1b eliminate ER retention of mGluR5, demonstrating that H1b affects metabotropic receptor localization via a direct protein-protein interaction. Electron microscopic analysis reveals that the group I metabotropic receptor mGluR1alpha is significantly enriched in the ER of Purkinje cells, suggesting that a similar mechanism may exist in vivo. Because H1b is found in dendritic spines of neurons, local retention of metabotropic receptors within dendritic ER provides a potential mechanism for regulating synapse-specific expression of group I metabotropic glutamate receptors."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.36.25953"xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.274.36.25953"xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Xiao B."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Xiao B."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Worley P.F."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Roche K.W."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Roche K.W."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Petralia R.S."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Petralia R.S."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Wenthold R.J."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Wenthold R.J."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Tu J.C."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/author | "Tu J.C."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/pages | "25953-25957"xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/pages | "25953-25957"xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/title | "Homer 1b regulates the trafficking of group I metabotropic glutamate receptors."xsd:string |
| http://purl.uniprot.org/citations/10464340 | http://purl.uniprot.org/core/title | "Homer 1b regulates the trafficking of group I metabotropic glutamate receptors."xsd:string |