| http://purl.uniprot.org/citations/10465784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10465784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10465784 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of NF-kappaB as a consequence of signaling through the Toll and IL-1 receptors is a major element of innate immune responses. We report the identification and characterization of a novel intermediate in these signaling pathways that bridges TRAF6 to MEKK-1. This adapter protein, which we have named ECSIT (evolutionarily conserved signaling intermediate in Toll pathways), is specific for the Toll/IL-1 pathways and is a regulator of MEKK-1 processing. Expression of wild-type ECSIT accelerates processing of MEKK-1, whereas a dominant-negative fragment of ECSIT blocks MEKK-1 processing and activation of NF-kappaB. These results indicate an important role for ECSIT in signaling to NF-kappaB and suggest that processing of MEKK-1 is required for its function in the Toll/IL-1 pathway."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.13.16.2059"xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.13.16.2059"xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Ghosh S."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Xiao C."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Xiao C."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Douglas I."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Douglas I."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Medzhitov R."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Medzhitov R."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Carothers J."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Carothers J."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Janeway C.A."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Janeway C.A."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Kopp E."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/author | "Kopp E."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/pages | "2059-2071"xsd:string |
| http://purl.uniprot.org/citations/10465784 | http://purl.uniprot.org/core/pages | "2059-2071"xsd:string |