| http://purl.uniprot.org/citations/10468580 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10468580 | http://www.w3.org/2000/01/rdf-schema#comment | "Interaction of syntaxin 1 with the alpha(1D) subunit of the voltage-gated L type Ca(2+) channel was investigated in the pancreatic beta cell. Coexpression of the enhanced green fluorescent protein-linked alpha(1D) subunit with the enhanced blue fluorescent protein-linked syntaxin 1 and Western blot analysis together with subcellular fractionation demonstrated that the alpha(1D) subunit and syntaxin 1 were colocalized in the plasma membrane. Furthermore, the alpha(1D) subunit was coimmunoprecipitated efficiently by a polyclonal antibody against syntaxin 1. Syntaxin 1 also played a central role in the modulation of L type Ca(2+) channel activity because there was a faster Ca(2+) current run-down in cells incubated with antisyntaxin 1 compared with controls. In parallel, antisyntaxin 1 markedly reduced insulin release in both intact and permeabilized cells, subsequent to depolarization with K(+) or exposure to high Ca(2+). Exchanging Ca(2+) for Ba(2+) abolished the effect of antisyntaxin 1 on both Ca(2+) channel activity and insulin exocytosis. Moreover, antisyntaxin 1 had no significant effects on Ca(2+)-independent insulin release trigged by hypertonic stimulation. This suggests that there is a structure-function relationship between the alpha(1D) subunit of the L type Ca(2+) channel and the exocytotic machinery in the pancreatic beta cell."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.18.10164"xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Larsson O."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Kohler M."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Bertorello A.M."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Yang S.N."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Leibiger B."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Meister B."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Berggren P.O."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Branstrom R."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Leibiger I.B."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/author | "Moede T."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/pages | "10164-10169"xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/title | "Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells."xsd:string |
| http://purl.uniprot.org/citations/10468580 | http://purl.uniprot.org/core/volume | "96"xsd:string |
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