| http://purl.uniprot.org/citations/10468607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10468607 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC class I molecules usually present peptides derived from endogenous antigens that are bound in the endoplasmic reticulum. Loading of exogenous antigens on class I molecules, e.g., in cross-priming, sometimes occurs, but the intracellular location where interaction between the antigenic fragment and class I takes place is unclear. Here we show that measles virus F protein can be presented by class I in transporters associated with antigen processing-independent, NH(4)Cl-sensitive manner, suggesting that class I molecules are able to interact and bind antigen in acidic compartments, like class II molecules. Studies on intracellular transport of green fluorescent protein-tagged class I molecules in living cells confirmed that a small fraction of class I molecules indeed enters classical MHC class II compartments (MIICs) and is transported in MIICs back to the plasma membrane. Fractionation studies show that class I complexes in MIICs contain peptides. The pH in MIIC (around 5.0) is such that efficient peptide exchange can occur. We thus present evidence for a pathway for class I loading that is shared with class II molecules."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.18.10326"xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "Janssen H."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "Neefjes J."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "Calafat J."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "Kenter M.J."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "Verwoerd D."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "van Binnendijk R.S."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "Uytdehaag F.G."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "Tulp A."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/author | "Gromme M."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/pages | "10326-10331"xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/title | "Recycling MHC class I molecules and endosomal peptide loading."xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10468607 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10468607 |
| http://purl.uniprot.org/citations/10468607 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10468607 |
| http://purl.uniprot.org/uniprot/#_P10321-mappedCitation-10468607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10468607 |
| http://purl.uniprot.org/uniprot/#_P13747-mappedCitation-10468607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10468607 |
| http://purl.uniprot.org/uniprot/#_P61769-mappedCitation-10468607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10468607 |
| http://purl.uniprot.org/uniprot/#_P30511-mappedCitation-10468607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10468607 |
| http://purl.uniprot.org/uniprot/#_P01889-mappedCitation-10468607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10468607 |
| http://purl.uniprot.org/uniprot/#_P01893-mappedCitation-10468607 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10468607 |