| http://purl.uniprot.org/citations/10468609 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10468609 | http://www.w3.org/2000/01/rdf-schema#comment | "MHC class II (MHC-II) molecules play a central role in the selection of the T cell repertoire, in the establishment and regulation of the adaptive immune response, and in autoimmune deviation. We have generated knockout mice lacking all four of the classical murine MHC-II genes (MHCII(Delta/Delta) mice), via a large (80-kilobase) deletion of the entire class II region that was engineered by homologous recombination and Cre recombinase-mediated excision. These mice feature immune system perturbations like those of Aalpha and Abeta knockout animals, notably a dearth of CD4(+) lymphocytes in the thymus and spleen. No new anatomical or physiological abnormalities were observed in MHCII(Delta/Delta) mice. Because these animals are devoid of all classical MHC-II chains, even unpaired chains, they make excellent recipients for MHC-II transgenes from other species, avoiding the problem of interspecies cross-pairing of MHC-II chains. Therefore, they should be invaluable for engineering "humanized" mouse models of human MHC-II-associated autoimmune disorders."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.18.10338"xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/author | "Dierich A."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/author | "Fugger L."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/author | "Madsen L."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/author | "Svejgaard A."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/author | "Engberg J."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/author | "Benoist C."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/author | "Mathis D."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/author | "Labrecque N."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/pages | "10338-10343"xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/title | "Mice lacking all conventional MHC class II genes."xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/10468609 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10468609 |
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