| http://purl.uniprot.org/citations/10469599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10469599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10469599 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibitory immunoreceptors downregulate signaling by recruiting Src homology 2 (SH2) domain-containing tyrosine and/or lipid phosphatases to activating receptor complexes [1]. There are indications that some inhibitory receptors might also perform other functions [2] [3]. In adherent macrophages, two inhibitory receptors, SHPS-1 and PIR-B, are the major proteins binding to the tyrosine phosphatase SHP-1. SHPS-1 also associates with two tyrosine-phosphorylated proteins (pp55 and pp130) and a protein tyrosine kinase [4]. Here, we have identified pp55 and pp130 as the adaptor molecules SKAP55hom/R (Src-kinase-associated protein of 55 kDa homologue) and FYB/SLAP-130 (Fyn-binding protein/SLP-76-associated protein of 130 kDa), respectively, and the tyrosine kinase activity as PYK2. Two distinct SHPS-1 complexes were formed, one containing SKAP55hom/R and FYB/SLAP-130, and the other containing PYK2. Recruitment of FYB/SLAP-130 to SHPS-1 required SKAP55hom/R, whereas PYK2 associated with SHPS-1 independently. Formation of both complexes was independent of SHP-1 and tyrosine phosphorylation of SHPS-1. Finally, tyrosine phosphorylation of members of the SHPS-1 complexes was regulated by integrin-mediated adhesion. Thus, SHPS-1 provides a scaffold for the assembly of multi-protein complexes that might both transmit adhesion-regulated signals and help terminate such signals through SHP-1-directed dephosphorylation. Other inhibitory immunoreceptors might have similar scaffold-like functions."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(99)80401-1"xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0960-9822(99)80401-1"xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Swanson K.D."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Swanson K.D."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Marie-Cardine A."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Raab M."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Raab M."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Schraven B."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Rudd C.E."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Neel B.G."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Neel B.G."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Timms J.F."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/author | "Timms J.F."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/name | "Curr. Biol."xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/pages | "927-930"xsd:string |
| http://purl.uniprot.org/citations/10469599 | http://purl.uniprot.org/core/pages | "927-930"xsd:string |