| http://purl.uniprot.org/citations/10471307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10471307 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10471307 | http://www.w3.org/2000/01/rdf-schema#comment | "Contryphan-R is a disulfide-constrained octapeptide containing a D-tryptophan that was isolated recently from venom of the cone shell Conus radiatus. The polypeptide is present in two forms in solution due to cis-trans isomerization at hydroxyproline 3. The solution structure of the major form of this unusual polypeptide, determined from NMR data, consists of a well-defined fold containing a non-hydrogen-bonded chain reversal from Gly1 to Glu5, which includes a cis-hydroxyproline and a D-Trp, and a type I beta-turn from Glu5 to Cys8. The presence of a putative salt bridge between the Glu5 carboxyl group and the N-terminal ammonium group is investigated by using various solvation models during energy minimization and is compared with the results of a pH titration. A comparison of the structure of contryphan-R with other cyclic peptide structures highlights some of the key structural determinants of these peptides and suggests that the contryphan-R fold could be exploited as a scaffold onto which unrelated protein binding surfaces could be grafted. Comparison with small disulfide-bridged loops in larger proteins shows that contryphan-R is similar to a commonly occurring loop structure found in proteins."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi990685j"xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.org/dc/terms/identifier | "doi:10.1021/bi990685j"xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Norton R.S."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Norton R.S."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Jimenez E.C."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Jimenez E.C."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Melnikova A.P."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Melnikova A.P."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Pallaghy P.K."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/author | "Pallaghy P.K."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/name | "Biochemistry"xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/pages | "11553-11559"xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/pages | "11553-11559"xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/title | "Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing D-tryptophan: comparison with protein loops."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/title | "Solution structure of contryphan-R, a naturally occurring disulfide-bridged octapeptide containing D-tryptophan: comparison with protein loops."xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/volume | "38"xsd:string |
| http://purl.uniprot.org/citations/10471307 | http://purl.uniprot.org/core/volume | "38"xsd:string |