| http://purl.uniprot.org/citations/10471399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10471399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10471399 | http://www.w3.org/2000/01/rdf-schema#comment | "We report here on the cloning and functional characterization of human SVCT2, a sodium-dependent vitamin C (ascorbate) transporter. The hSVCT2 cDNA obtained from a human placental choriocarcinoma cell cDNA library, codes for a protein of 650 amino acids with a predicted molecular mass of 70 kDa. At the level of amino acid sequence, the human SVCT2 exhibits 95% identity to its rat homolog. When functionally expressed in mammalian cells, hSVCT2 induces the transport of ascorbic acid. The transport process induced by hSVCT2 is Na(+)-dependent and is specific for ascorbate. The Michaelis-Menton constant (K(t)) for the transport of ascorbate in cDNA-transfected cells is 69 +/-5 microM. The relationship between the cDNA-specific uptake rate of ascorbate and Na(+) concentration is sigmoidal with a Na(+):ascorbate stoichiometry of 2:1. Northern blot analysis shows that SVCT2-specific transcripts are present in heart, brain, placenta, and liver and is absent in lung and skeletal muscle. The size of the principal transcript is approximately 7.5 kb."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.1272"xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.org/dc/terms/identifier | "doi:10.1006/bbrc.1999.1272"xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Huang W."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Ganapathy V."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Ganapathy V."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Leibach F.H."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Leibach F.H."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Prasad P.D."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Prasad P.D."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Rajan D.P."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Rajan D.P."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Dutta B."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Dutta B."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Devoe L.D."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/author | "Devoe L.D."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/pages | "762-768"xsd:string |
| http://purl.uniprot.org/citations/10471399 | http://purl.uniprot.org/core/pages | "762-768"xsd:string |