| http://purl.uniprot.org/citations/10476970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10476970 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10476970 | http://www.w3.org/2000/01/rdf-schema#comment | "Many receptors for neuropeptides and hormones are coupled with the heterotrimeric G(i) protein, which activates the p42/44 mitogen-activated protein kinase (ERK/MAPK) cascade through both the alpha- and betagamma-subunits of G(i). The betagamma-subunit activates the ERK/MAPK cascade through tyrosine kinase. Constitutively active G(alpha)i2 (gip2) isolated from adrenal and ovarian tumours transforms Rat-1 fibroblasts and also activates the ERK/MAPK cascade by an unknown mechanism. The ERK/MAPK pathway is activated by Ras, and is inhibited when the low-molecular-mass GTP-binding protein Rap1 antagonizes Ras function. Here we show that a novel isoform of Rapl GTPase-activating protein, called rap1GAPII, binds specifically to the alpha-subunits of the G(i) family of heterotrimeric G-proteins. Stimulation of the G(i)-coupled m2-muscarinic receptor translocates rap1GAPII from the cytosol to the membrane and decreases the amount of GTP-bound Rap1. This decrease in GTP-bound Rap1 activates ERK/MAPK. Thus, the alpha-subunit of G(i) activates the Ras-ERK/MAPK mitogenic pathway by membrane recruitment of rap1GAPII and reduction of GTP-bound Rap1."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.org/dc/terms/identifier | "doi:10.1038/23738"xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.org/dc/terms/identifier | "doi:10.1038/23738"xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Murakami Y."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Matsuda M."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Nagashima K."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Nagashima K."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Ohba Y."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Ohba Y."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Ozaki Y."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Ozaki Y."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Kurata T."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Kurata T."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Mochizuki N."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Mochizuki N."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Kiyokawa E."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Kiyokawa E."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Kitakabe A."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/author | "Kitakabe A."xsd:string |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10476970 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |