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http://purl.uniprot.org/citations/10477523http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10477523http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10477523http://www.w3.org/2000/01/rdf-schema#comment"Polyadenylation of messenger RNA precursors requires a complex protein machinery that is closely integrated with the even more complex transcriptional apparatus. Here a polyadenylation factor, CstF-50 (cleavage stimulation factor), is shown to interact in vitro and in intact cells with a nuclear protein of previously unknown function, BRCA1-associated RING domain protein (BARD1). The BARD1-CstF-50 interaction inhibits polyadenylation in vitro. BARD1, like CstF-50, also interacts with RNA polymerase II. These results indicate that BARD1-mediated inhibition of polyadenylation may prevent inappropriate RNA processing during transcription, perhaps at sites of DNA repair, and they reveal an unanticipated integration of diverse nuclear events."xsd:string
http://purl.uniprot.org/citations/10477523http://purl.org/dc/terms/identifier"doi:10.1126/science.285.5433.1576"xsd:string
http://purl.uniprot.org/citations/10477523http://purl.org/dc/terms/identifier"doi:10.1126/science.285.5433.1576"xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/author"Manley J.L."xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/author"Manley J.L."xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/author"Kleiman F.E."xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/author"Kleiman F.E."xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/pages"1576-1579"xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/pages"1576-1579"xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/title"Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50."xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/title"Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50."xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/volume"285"xsd:string
http://purl.uniprot.org/citations/10477523http://purl.uniprot.org/core/volume"285"xsd:string
http://purl.uniprot.org/citations/10477523http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10477523
http://purl.uniprot.org/citations/10477523http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10477523
http://purl.uniprot.org/citations/10477523http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10477523
http://purl.uniprot.org/citations/10477523http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/10477523
http://purl.uniprot.org/uniprot/Q99728http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/10477523
http://purl.uniprot.org/uniprot/Q05048http://purl.uniprot.org/core/citationhttp://purl.uniprot.org/citations/10477523