| http://purl.uniprot.org/citations/10482244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10482244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10482244 | http://www.w3.org/2000/01/rdf-schema#comment | "It is hypothesized that Ca2+ stimulation of calmodulin (CaM)-activated adenylyl cyclases (AC1 or AC8) generates cAMP signals critical for late phase LTP (L-LTP) and long-term memory (LTM). However, mice lacking either AC1 or AC8 exhibit normal L-LTP and LTM. Here, we report that mice lacking both enzymes (DKO) do not exhibit L-LTP or LTM. To determine if these defects are due to a loss of cAMP increases in the hippocampus, DKO mice were unilaterally cannulated to deliver forskolin. Administration of forskolin to area CA1 before training restored normal LTM. We conclude that Ca2+-stimulated adenylyl cyclase activity is essential for L-LTP and LTM and that AC1 or AC8 can produce the necessary cAMP signal."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(01)80036-2"xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0896-6273(01)80036-2"xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Storm D.R."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Storm D.R."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Athos J."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Athos J."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Chavkin C.C."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Chavkin C.C."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Figueroa X.A."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Figueroa X.A."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Muglia L.J."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Muglia L.J."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Pineda V.V."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Pineda V.V."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Schaefer M.L."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Schaefer M.L."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Wong S.T."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/author | "Wong S.T."xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/10482244 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |