| http://purl.uniprot.org/citations/10485710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10485710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10485710 | http://www.w3.org/2000/01/rdf-schema#comment | "Activation of the nuclear transcription factor NF-kappaB by inflammatory cytokines requires the successive action of NF-kappaB-inducing kinase (NIK) and an IKB-kinase (IKK) complex composed of IKKalpha and IKKbeta. Here we show that the Akt serine-threonine kinase is involved in the activation of NF-kappaB by tumour necrosis factor (TNF). TNF activates phosphatidylinositol-3-OH kinase (PI(3)K) and its downstream target Akt (protein kinase B). Wortmannin (a PI(3)K inhibitor), dominant-negative PI(3)K or kinase-dead Akt inhibits TNF-mediated NF-kappaB activation. Constitutively active Akt induces NF-kappaB activity and this effect is blocked by dominant-negative NIK. Conversely, NIK activates NF-kappaB and this is blocked by kinase-dead Akt. Thus, both Akt and NIK are necessary for TNF activation of NF-kappaB. Akt mediates IKKalpha phosphorylation at threonine 23. Mutation of this amino acid blocks phosphorylation by Akt or TNF and activation of NF-kappaB. These findings indicate that Akt is part of a signalling pathway that is necessary for inducing key immune and inflammatory responses."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.org/dc/terms/identifier | "doi:10.1038/43466"xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.org/dc/terms/identifier | "doi:10.1038/43466"xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Pfeffer S.R."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Pfeffer S.R."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Donner D.B."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Donner D.B."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Pfeffer L.M."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Pfeffer L.M."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Gustin J.A."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Gustin J.A."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Mayo L.D."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Mayo L.D."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Ozes O.N."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/author | "Ozes O.N."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/pages | "82-85"xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/pages | "82-85"xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/title | "NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase."xsd:string |
| http://purl.uniprot.org/citations/10485710 | http://purl.uniprot.org/core/title | "NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase."xsd:string |