| http://purl.uniprot.org/citations/10488331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10488331 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10488331 | http://www.w3.org/2000/01/rdf-schema#comment | "We have solved the high-resolution X-ray structure of 14-3-3 bound to two different phosphoserine peptides, representing alternative substrate-binding motifs. These structures reveal an evolutionarily conserved network of peptide-protein interactions within all 14-3-3 isotypes, explain both binding motifs, and identify a novel intrachain phosphorylation-mediated loop structure in one of the peptides. A 14-3-3 mutation disrupting Raf signaling alters the ligand-binding cleft, selecting a different phosphopeptide-binding motif and different substrates than the wild-type protein. Many 14-3-3: peptide contacts involve a C-terminal amphipathic alpha helix containing a putative nuclear export signal, implicating this segment in both ligand and Crm1 binding. Structural homology between the 14-3-3 NES structure and those within I kappa B alpha and p53 reveals a conserved topology recognized by the Crm1 nuclear export machinery."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)80363-9"xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.org/dc/terms/identifier | "doi:10.1016/s1097-2765(00)80363-9"xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Budman J."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Budman J."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Cantley L.C."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Cantley L.C."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Gamblin S.J."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Gamblin S.J."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Rittinger K."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Rittinger K."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Smerdon S.J."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Smerdon S.J."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Volinia S."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Volinia S."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/10488331 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |