| http://purl.uniprot.org/citations/10490661 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10490661 | http://www.w3.org/2000/01/rdf-schema#comment | "The BCL-6 proto-oncogene encodes a POZ/zinc-finger transcription factor that is expressed in B cells and a subset of CD4(+) T cells within germinal centers. Recent evidence suggests that BCL-6 can act as a sequence-specific repressor of transcription, but the target genes for this activity have not yet been identified. The binding site for BCL-6 shares striking homology to the sites that are the target sequence for the interleukin-4 (IL-4)-induced Stat6 (signal transducers and activators of transcription) signaling molecule. Electrophoretic mobility shift assays demonstrate that BCL-6 can bind, with different affinities, to several DNA elements recognized by Stat6. Expression of BCL-6 can repress the IL-4-dependent induction of immunoglobulin (Ig) germ line epsilon transcripts, but does not repress the IL-4 induction of CD23 transcripts. Consistent with the role of BCL-6 in modulating transcription from the germ line epsilon promoter, BCL-6(-/-) mice display an increased ability to class switch to IgE in response to IL-4 in vitro. These animals also exhibit a multiorgan inflammatory disease characterized by the presence of a large number of IgE(+) B cells. The apparent dysregulation of IgE production is abolished in BCL-6(-/-) Stat6(-/-) mice, indicating that BCL-6 regulation of Ig class switching is dependent upon Stat6 signaling. Thus, BCL-6 can modulate the transcription of selective Stat6-dependent IL-4 responses, including IgE class switching in B cells."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.19.10.7264"xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Chang C.C."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Berton M.T."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Pandolfi P.P."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Dalla-Favera R."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Danial N.N."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Ye B.H."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Cattoretti G."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Rothman P.B."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Kvatyuk M."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Harris M.B."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/author | "Kuehner D."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/pages | "7264-7275"xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/title | "Transcriptional repression of Stat6-dependent interleukin-4-induced genes by BCL-6: specific regulation of iepsilon transcription and immunoglobulin E switching."xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/10490661 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10490661 |
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| http://purl.uniprot.org/uniprot/P41183#attribution-A6E6383BB4597787BB8196DD7A4D3BD1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10490661 |
| http://purl.uniprot.org/uniprot/P41183#attribution-F6ADB1B13B2FA7EEF3A5B28648AB0443 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10490661 |
| http://purl.uniprot.org/uniprot/Q5ZM39#attribution-43E92A258D681203C2FDE7B1F06B2801 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10490661 |