| http://purl.uniprot.org/citations/10499802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10499802 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10499802 | http://www.w3.org/2000/01/rdf-schema#comment | "We present evidence that phosphorylation of the C-terminal region of Rb by Cdk4/6 initiates successive intramolecular interactions between the C-terminal region and the central pocket. The initial interaction displaces histone deacetylase from the pocket, blocking active transcriptional repression by Rb. This facilitates a second interaction that leads to phosphorylation of the pocket by Cdk2 and disruption of pocket structure. These intramolecular interactions provide a molecular basis for sequential phosphorylation of Rb by Cdk4/6 and Cdk2. Cdk4/6 is activated early in G1, blocking active repression by Rb. However, it is not until near the end of G1, when cyclin E is expressed and Cdk2 is activated, that Rb is prevented from binding and inactivating E2F."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81519-6"xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0092-8674(00)81519-6"xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Dean D.C."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Dean D.C."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Dei Santi A."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Dei Santi A."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Harbour J.W."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Harbour J.W."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Luo R.X."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Luo R.X."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Postigo A.A."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/author | "Postigo A.A."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/pages | "859-869"xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/pages | "859-869"xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/title | "Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/title | "Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1."xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/volume | "98"xsd:string |
| http://purl.uniprot.org/citations/10499802 | http://purl.uniprot.org/core/volume | "98"xsd:string |