| http://purl.uniprot.org/citations/10500184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10500184 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10500184 | http://www.w3.org/2000/01/rdf-schema#comment | "Asymmetric expression of Sonic hedgehog (Shh) in Hensen's node of the chicken embryo plays a key role in the genetic cascade that controls left-right asymmetry, but its involvement in left-right specification in other vertebrates remains unclear. We show that mouse embryos lacking Shh display a variety of laterality defects, including pulmonary left isomerism, alterations of heart looping, and randomization of axial turning. Expression of the left-specific gene Lefty-1 is absent in Shh(-/-) embryos, suggesting that the observed laterality defects could be the result of the lack of Lefty-1. We also demonstrate that retinoic acid (RA) controls Lefty-1 expression in a pathway downstream or parallel to Shh. Further, we provide evidence that RA controls left-right development across vertebrate species. Thus, the roles of Shh and RA in left-right specification indeed are conserved among vertebrates, and the Shh and RA pathways converge in the control of Lefty-1."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.20.11376"xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.96.20.11376"xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Tamura K."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Tamura K."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Evans R.M."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Blumberg B."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Blumberg B."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Capdevila J."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Capdevila J."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Tsukui T."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Tsukui T."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Izpisua Belmonte J.C."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Ruiz-Lozano P."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Ruiz-Lozano P."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Izpisua-Belmonte J.-C."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Izpisua-Belmonte J.-C."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Chien K."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Chien K."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Chandraratna R.A.S."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Chandraratna R.A.S."xsd:string |
| http://purl.uniprot.org/citations/10500184 | http://purl.uniprot.org/core/author | "Rodriguez-Esteban C."xsd:string |