| http://purl.uniprot.org/citations/10508865 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10508865 | http://www.w3.org/2000/01/rdf-schema#comment | "Tight junctions (TJs) in endothelial cells are thought to determine vascular permeability. Recently, claudin-1 to -15 were identified as major components of TJ strands. Among these, claudin-5 (also called transmembrane protein deleted in velo-cardio-facial syndrome [TMVCF]) was expressed ubiquitously, even in organs lacking epithelial tissues, suggesting the possible involvement of this claudin species in endothelial TJs. We then obtained a claudin-6-specific polyclonal antibody and a polyclonal antibody that recognized both claudin-5/TMVCF and claudin-6. In the brain and lung, immunofluorescence microscopy with these polyclonal antibodies showed that claudin-5/TMVCF was exclusively concentrated at cell-cell borders of endothelial cells of all segments of blood vessels, but not at those of epithelial cells. Immunoreplica electron microscopy revealed that claudin-5/TMVCF was a component of TJ strands. In contrast, in the kidney, the claudin-5/TMVCF signal was restricted to endothelial cells of arteries, but was undetectable in those of veins and capillaries. In addition, in all other tissues we examined, claudin-5/TMVCF was specifically detected in endothelial cells of some segments of blood vessels, but not in epithelial cells. Furthermore, when claudin-5/TMVCF cDNA was introduced into mouse L fibroblasts, TJ strands were reconstituted that resembled those in endothelial cells in vivo, i.e., the extracellular face-associated TJs. These findings indicated that claudin-5/TMVCF is an endothelial cell-specific component of TJ strands."xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.147.1.185"xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/author | "Tsukita S."xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/author | "Sasaki H."xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/author | "Morita K."xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/author | "Furuse M."xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/pages | "185-194"xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/title | "Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells."xsd:string |
| http://purl.uniprot.org/citations/10508865 | http://purl.uniprot.org/core/volume | "147"xsd:string |
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