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http://purl.uniprot.org/citations/10508922http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10508922http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/10508922http://www.w3.org/2000/01/rdf-schema#comment"Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.org/dc/terms/identifier"doi:10.1016/S0014-5793(99)01214-4"xsd:string
http://purl.uniprot.org/citations/10508922http://purl.org/dc/terms/identifier"doi:10.1016/s0014-5793(99)01214-4"xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/author"Wang X."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/author"Tang J."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/author"Tang J."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/author"Zhang X.C."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/author"Zhang X.C."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/author"Hunter B."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/author"Hunter B."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/date"1999"xsd:gYear
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/name"FEBS Lett."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/name"FEBS Lett"xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/pages"85-89"xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/pages"85-89"xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/title"Crystal structure of streptokinase beta-domain."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/title"Crystal structure of streptokinase beta-domain."xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/volume"459"xsd:string
http://purl.uniprot.org/citations/10508922http://purl.uniprot.org/core/volume"459"xsd:string
http://purl.uniprot.org/citations/10508922http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10508922
http://purl.uniprot.org/citations/10508922http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/10508922