| http://purl.uniprot.org/citations/10508933 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10508933 | http://www.w3.org/2000/01/rdf-schema#comment | "Tryptase-like activities of T and NK cells contribute to the induction of target cell apoptosis, but only granzyme A (GzmA) has been shown to exhibit Z-Lys-SBzl esterase activity in murine T cells. GzmA-deficient mice exhibit residual Z-Lys-SBzl hydrolyzing activity and almost normal levels of lymphocyte-mediated cytotoxicity. Here we report the cloning and biochemical characterization of recombinant mouse granzyme K (GzmK). The purified murine protein shows Z-Lys-SBzl hydrolyzing activity and is inhibited by bikunin, the light chain of inter-alpha-trypsin inhibitor, like the human homolog. We conclude that GzmK expressed by GzmA-deficient T cells accounts for the remaining Z-Lys-SBzl activity. Functional similarities between GzmA and GzmK may explain the subtle immunological deficits observed in GzmA-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/10508933 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0014-5793(99)01200-4"xsd:string |
| http://purl.uniprot.org/citations/10508933 | http://purl.uniprot.org/core/author | "Tschopp J."xsd:string |
| http://purl.uniprot.org/citations/10508933 | http://purl.uniprot.org/core/author | "Jenne D.E."xsd:string |
| http://purl.uniprot.org/citations/10508933 | http://purl.uniprot.org/core/author | "Wilharm E."xsd:string |
| http://purl.uniprot.org/citations/10508933 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10508933 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/10508933 | http://purl.uniprot.org/core/pages | "139-142"xsd:string |
| http://purl.uniprot.org/citations/10508933 | http://purl.uniprot.org/core/title | "Biological activities of granzyme K are conserved in the mouse and account for residual Z-Lys-SBzl activity in granzyme A-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/10508933 | http://purl.uniprot.org/core/volume | "459"xsd:string |
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