| http://purl.uniprot.org/citations/10510314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10510314 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor-1 (FGF-1), which lacks a signal peptide and is intracellularly localized as a result of endogenous expression or endocytosis, is thought to be involved in regulating cell growth and differentiation. In the study reported here, we purified proteins that bind intracellular FGF-1. Affinity adsorption was used to purify FGF-1-binding proteins from rat L6 cells expressing FGF-1. One of the isolated proteins was identified as the glucose-regulated protein GRP75/mortalin/PBP-74/mthsp70, a member of the hsp70 family of heat-shock proteins known to be involved in regulating glucose responses, antigen processing and cell mortality. The interaction of FGF-1 and GRP75/mortalin in vivo was confirmed by co-immunoprecipitation, immunohistochemical co-localization in Rat-1 fibroblasts and by using the yeast two-hybrid system. Moreover, a binding assay in vitro with the use of recombinant FGF-1 and mortalin demonstrated a direct physical interaction between the two proteins. These results reveal that GRP75/mortalin is an intracellular FGF-1-binding protein in cells and suggest that GRP75/mortalin is involved in the trafficking of and/or signalling by FGF-1."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj3430461"xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Hayashi H."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Mizukoshi E."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Suzuki M."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Imamura T."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Kaul S.C."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Wadhwa R."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Uruno T."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Loupatov A."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/author | "Misono T."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/pages | "461-466"xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/title | "Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin."xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://purl.uniprot.org/core/volume | "343"xsd:string |
| http://purl.uniprot.org/citations/10510314 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10510314 |
| http://purl.uniprot.org/citations/10510314 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10510314 |
| http://purl.uniprot.org/uniprot/P61149#attribution-B439A65C5EC70BB1FE829F4705305FAF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10510314 |
| http://purl.uniprot.org/uniprot/P48721#attribution-B439A65C5EC70BB1FE829F4705305FAF | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/10510314 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZR52-mappedCitation-10510314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510314 |
| http://purl.uniprot.org/uniprot/#_A0A7U3JW64-mappedCitation-10510314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510314 |
| http://purl.uniprot.org/uniprot/#_F1M953-mappedCitation-10510314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510314 |
| http://purl.uniprot.org/uniprot/#_P48721-mappedCitation-10510314 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510314 |