| http://purl.uniprot.org/citations/10510343 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10510343 | http://www.w3.org/2000/01/rdf-schema#comment | "TCR alpha beta+ intestinal intraepithelial lymphocytes (IEL) can express either the typical CD8 alpha beta heterodimer or an unusual CD8 alpha alpha homodimer. Both types of CD8+ IEL require class I molecules for their differentiation, since they are absent in beta2m-/-mice. To gain insight into the role of class I molecules in forming TCR alpha beta+ CD8+ IEL populations, we have analyzed the IEL in mice deficient for either TAP, beta 2m, CD1, or K and D. We find that K-/-D-/-mice have TCR alpha beta+ CD8 alpha alpha+ IEL, although they are deficient for TCR alpha beta+ CD8 alpha beta+ cells. This indicates that at least some TCR alpha beta+ CD8 alpha alpha+ IEL require only nonclassical class I molecules for their development. Surprisingly, the TCR alpha beta+ CD8 alpha alpha+ IEL are significantly increased in K-/-D-/-mice, suggesting a complex interaction between CD8+ IEL and class I molecules that might include direct or indirect negative regulation by K and D, as well as positive effects mediated by nonclassical class I molecules."xsd:string |
| http://purl.uniprot.org/citations/10510343 | http://purl.uniprot.org/core/author | "Kronenberg M."xsd:string |
| http://purl.uniprot.org/citations/10510343 | http://purl.uniprot.org/core/author | "Cheroutre H."xsd:string |
| http://purl.uniprot.org/citations/10510343 | http://purl.uniprot.org/core/author | "Gapin L."xsd:string |
| http://purl.uniprot.org/citations/10510343 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10510343 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10510343 | http://purl.uniprot.org/core/pages | "4100-4104"xsd:string |
| http://purl.uniprot.org/citations/10510343 | http://purl.uniprot.org/core/title | "Cutting edge: TCR alpha beta+ CD8 alpha alpha+ T cells are found in intestinal intraepithelial lymphocytes of mice that lack classical MHC class I molecules."xsd:string |
| http://purl.uniprot.org/citations/10510343 | http://purl.uniprot.org/core/volume | "163"xsd:string |
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