| http://purl.uniprot.org/citations/10510355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/10510355 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-4 has multiple effects on B lymphocytes, many of which are concentration dependent. This is particularly so for Ig isotype switching, where different thresholds of IL-4 stimulation are needed to induce switching from IgM to either IgG1 or IgE. In this report we describe a critical role for the tyrosine kinase Lyn in setting IL-4 signaling thresholds in mouse B lymphocytes. Upon CD40 ligand stimulation of lyn-/-B cells, 10-fold less IL-4 was required to induce switching from IgM to IgG1 and IgE and an increased proportion of B cells isotype switched at each IL-4 concentration. These in vitro results correlate with the in vivo findings that in lyn-/-mice, IgG1 Ab-forming cells develop prematurely in ontogeny and that adult lyn-/-mice have an abnormally high proportion of IgG1-expressing B cells in their spleens. Adult lyn-/-mice also have significantly higher levels of IgE in their serum. These results identify Lyn as a molecule involved in modulating the IL-4 signal in B cells and provide insights into its regulation and how a B cell signaling imbalance may contribute to atopy."xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/author | "Hibbs M."xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/author | "Janas M.L."xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/author | "Tarlinton D."xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/author | "Hodgkin P."xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/date | "1999"xsd:gYear |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/pages | "4192-4198"xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/title | "Genetic evidence for Lyn as a negative regulator of IL-4 signaling."xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://purl.uniprot.org/core/volume | "163"xsd:string |
| http://purl.uniprot.org/citations/10510355 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/10510355 |
| http://purl.uniprot.org/citations/10510355 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/10510355 |
| http://purl.uniprot.org/uniprot/#_P25911-mappedCitation-10510355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/#_Q05DV0-mappedCitation-10510355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/#_Q3TCS3-mappedCitation-10510355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/#_Q3U6Q5-mappedCitation-10510355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/#_Q8CEI0-mappedCitation-10510355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/Q8CEI0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/P25911 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/Q3TCS3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/Q05DV0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10510355 |
| http://purl.uniprot.org/uniprot/Q3U6Q5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/10510355 |